Hydrophilic extract fromPosidonia oceanicainhibits activity and expression of gelatinases and prevents HT1080 human fibrosarcoma cell line invasion
نویسندگان
چکیده
منابع مشابه
Hydrophilic extract from Posidonia oceanica inhibits activity and expression of gelatinases and prevents HT1080 human fibrosarcoma cell line invasion
Posidonia oceanica (L.) Delile is an endemic Mediterranean sea-grass distributed in the infralittoral zones, where it forms meadows playing a recognized ecological role in the coastal marine habitat. Although its use as a traditional herbal remedy is poorly documented, recent literature reports interesting pharmacological activities as antidiabetic, antioxidant and vasoprotective. Differently f...
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Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT1080 fibrosarcoma cells.
Membrane vesicles are shed by tumor cells both in vivo and in vitro. Although their functions are not well understood, it has been proposed that they may play multiple roles in tumor progression. We characterized membrane vesicles from human HT1080 fibrosarcoma cell cultures for the presence of proteinases involved in tumor invasion. By gelatin zymography and Western blotting, these vesicles sh...
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To explore the feasibilityof targeting human tumor cells via their trans port systems, dipeptide uptake was Studied in the human fibrosarcoma cell line HT1OSOand the human fibroblast cell line IMR-90 by the use of hydrol ysis-resistant glycytsarcosine (Gly-Sar). The uptake of [†̃4CJGly-Sar into HT1OSOwas time dependent Kinetic analysis of the concentration depend ence ofthe initial rate of['4C...
متن کاملCD133+ subpopulation of the HT1080 human fibrosarcoma cell line exhibits cancer stem-like characteristics.
The cancer stem cell (CSC) theory holds that a minority population within tumors possesses stem cell properties of self-renewal and multilineage differentiation capacity and provides the initiating cells from which tumors are derived and sustained. However, verifying the existence of these CSCs has been a significant challenge. The CD133 antigen is a pentaspan membrane glycoprotein proposed to ...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2015
ISSN: 1933-6918,1933-6926
DOI: 10.1080/19336918.2015.1008330